4-Methylethcathinone (also known as 4-MEC) is an entactogenic stimulant substance of the cathinone class.
It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa. It comes in the form of a powder, which users can swallow, snort, inject or insert rectally producing effects which are somewhat similar to that MDMA, amphetamine, and cocaine.
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4-MEC, or 4-methylethcathinone, is a synthetic molecule of the cathinone family. Cathinones are structurally similar to amphetamines, they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. Amphetamines and cathinones are alpha-methylated phenethylamines, cathinones contain an additional carbonyl group at R1. 4-MEC contains an additional ethyl substitutions at RN and a methyl substitution at R4 of its phenyl ring.
Given its chemical structure, 4-MEC is likely to act as a releasing agent and a reuptake inhibitor for monoamine neurotransmitters such as dopamine, serotonin and noradrenaline. 4-MEC is likely to have a similar pharmacological profile to mephedrone.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
Stimulation – In terms of its effects on the user’s physical energy levels, 4-MEC is commonly considered to be extremely stimulating and energetic. This encourages activities such as running, climbing and dancing in a way that makes 4-MEC a popular choice for musical events such as festivals and raves. The particular style of stimulation which mekhedrone presents can be described as forced. This means that at higher dosages it becomes difficult or impossible to keep still, as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in an extreme unsteadiness of the hands and a general lack of motor control.